Tiannan Guo
Siu Kwan SZE, Newman
School of Biological Sciences
Nanyang Technological University
Oi Lian KON
National Cancer Centre, Singapore
  Duke-NUS Graduate Medical School Singapore


Research Interest    
mass spectrometry; proteomics; cancer.  
Selected Publications pubmed  
  1. Tiannan Guo, Yi Zhu, Chee Sian Gan, Sze Sing Lee, Jiang Zhu, Haixia Wang, Xin Li, James Christensen, Shiang Huang, Oi Lian Kon*, and Siu Kwan Sze*. Quantitative proteomics discloses MET expression in mitochondria as a direct target of MET kinase inhibitor in cancer cells. Molecular and Cellular Proteomics. (2010)2010. 9(12):2629-41.
  2. Tiannan Guo, Sze Sing Lee, Wai Har Ng, Yi Zhu, Chee Sian Gan, Jiang Zhu, Haixia Wang, Shiang Huang, Siu Kwan Sze*, Oi Lian Kon* .Global Molecular Dysfunctions in Gastric Cancer Revealed by an Integrated Analysis of the Phosphoproteome and Transcriptome. Cellular and Molecular Life Sciences. (2010) in press
  3. Zhu Yi, Tiannan Guo, Siu Kwan Sze. Elucidating Structural Dynamics of Integral Membrane Proteins on Native Cell Surface by Hydroxyl Radical Footprinting and Mass Spectrometry. Human Protein Atlas of Section 4 - Nanotechnology techniques in proteomics: Potential Applications for Health and Disease.(in press)
  4. Tiannan Guo, Chee Sian Gan, Huoming Zhang, Yi Zhu, Oi Lian Kon, Siu Kwan Sze. Hybridization of Pulsed-Q Dissociation and Collision-Activated Dissociation in Linear Ion Trap Mass Spectrometer for iTRAQ Quantitation. Journal of Proteome Research, 2008, 7 (11), 4831-4840.
  5. Yi Zhu, Tiannan Guo, Jung Eun Park, Xin Li, Wei Meng, Arnab Datta, Marshall Bern, Sai Kiang Lim and Siu Kwan Sze. Elucidating in vivo Dynamic Structural Changes in Integral Membrane Proteins by Hydroxyl Radical Based Footprinting. Molecular and Cellular Proteomics. 2009 Aug;8(8):1999-2010.
  6. Huoming Zhang, Tiannan Guo, Xin Li, Arnab Datta, Jung Eun Park, Jie Yang, Sai Kiang Lim, James Tam and Siu Kwan Sze. Simultaneous characterization of glyco- and phosphoproteomes of mouse brain membrane proteome with electrostatic repulsion hydrophilic interaction chromatography. Molecular and Cellular Proteomics.,2010 Apr;9(4):635-47. (2010).
  7. Chee Sian Gan, Tiannan Guo, Huoming Zhang, Sai Kiang Lim, Siu Kwan Sze. A Comparative Study of Electrostatic Repulsion-Hydrophilic Interaction Chromatography (ERLIC) versus SCX-IMAC-Based Methods for Phosphopeptide Isolation/Enrichment. Journal of Proteome Research, 2008. 7 (11), 4869-4877.
  8. Piliang Hao, Tiannan Guo, Xin Li, Adav Sunil, Jie Yang, Wei Meng, Siu Kwan Sze. Novel Application of Electrostatic Repulsion-Hydrophilic Interaction Chromatography (ERLIC) in Shotgun Proteomics: Comprehensive Profiling of Rat Kidney Proteome. Journal of Proteome Research. 2010 Jul 2;9(7):3520-6.
  9. Wei Meng, Huoming Zhang, Tiannan Guo, Chhiti Pandey, Yi Zhu, Oi Lian Kon, Siu Kwan Sze. A one-step precedure for peptide extraction from in-gel digestion sample for mass spectrometric analysis. Analytical Chemistry, 2008. 80 (24), 9797–9805.
  10. Siu Kwan Sze*, Wei Wang, Wei Meng, Randong Yuan, Tiannan Guo,Yi Zhu, James P. Tam*. Elucidating structure of cyclotide by partial acid hydrolysis and LC-MS/MS analysis. Analytical Chemistry.2009, 81, (3), 1079-88.
updated Dec, 2010.  







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