Selected Publications

Tiannan Guo, Sze Sing Lee, Wai Har Ng, Yi Zhu, Chee Sian Gan, Jiang Zhu, Haixia Wang, Shiang Huang, Siu Kwan Sze*, Oi Lian Kon*

Global Molecular Dysfunctions in Gastric Cancer Revealed by an Integrated Analysis of the Phosphoproteome and Transcriptome

Cellular and Molecular Life Sciences. (2010) in press (PDF)


Tiannan Guo, Yi Zhu, Chee Sian Gan, Sze Sing Lee, Jiang Zhu, Haixia Wang, Xin Li, James Christensen, Shiang Huang, Oi Lian Kon*, and Siu Kwan Sze*

Quantitative proteomics discloses MET expression in mitochondria as a direct target of MET kinase inhibitor in cancer cells

Molecular and Cellular Proteomics. (2010) in press (PDF)


Sunil S. Adav, An A. Li, Arulmani Manavalan, Peter Punt and Siu Kwan Sze.

Quantitative iTRAQ Secretome Analysis of Aspergillus niger Reveals Novel Hydrolytic Enzymes.

Journal of Proteome Research., 2010, 9 (8), pp 3932–3940.


Piliang Hao, Tiannan Guo, Xin Li, Adav Sunil, Jie Yang, Wei Meng, Siu Kwan Sze.

Novel Application of Electrostatic Repulsion-Hydrophilic Interaction Chromatography (ERLIC) in Shotgun Proteomics: Comprehensive Profiling of Rat Kidney Proteome.

Journal of Proteome Research. (in press) Impact: 5.7 (PDF)


Sunil S. Adav, Chee Sheng Ng, Manavalan Arulmani and Siu Kwan Sze.

Quantitative iTRAQ Secretome Analysis of Cellulolytic Thermobifida fusca

Journal of Proteome Research. (in press) Impact: 5.7 (PDF)


Huoming Zhang, Changqing Zhao, Xin Li, Yi Zhu, Chee Sian Gan, Yong Wang, Timothy Ravasi, Peiyuan Qian, Siew Chung Wong, Siu Kwan Sze.

Study of monocyte membrane proteome perturbation during lipopolysaccharide-induced tolerance using iTRAQ-based quantitative proteomic approach

Proteomics. Impact 4.5 (in press)


Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.

Hypoxia modulates tumor microenvironment to enhance angiogenic and metastastic potential by secretion of proteins and exosomes.

Mol Cell Proteomics. Impact factor: 8.8, 2010 Feb 1.


Zhang H, Guo T, Li X, Datta A, Park JE, Yang J, Lim SK, Tam JP, Sze SK.

Simultaneous characterization of glyco- and phosphoproteomes of mouse brain membrane proteome with electrostatic repulsion hydrophilic interaction chromatography.

Mol Cell Proteomics. Impact factor: 8.8,2010 Apr;9(4):635-47. Epub 2010 Jan 4. PDF


Datta A, Park JE, Li X, Zhang H, Ho ZS, Heese K, Lim SK, Tam JP, Sze SK.

Phenotyping of an in vitro model of ischemic penumbra by iTRAQ-based shotgun quantitative proteomics.

J Proteome Res. Impact factor: 5.7, 2010 Jan;9(1):472-84.


Yi Zhu, Tiannan Guo, Jung Eun Park, Xin Li, Wei Meng, Arnab Datta, Marshall Bern, Sai Kiang Lim and Siu Kwan Sze.

Elucidating in vivo Dynamic Structural Changes in Integral Membrane Proteins by Hydroxyl Radical Based Footprinting.

Molecular and Cellular Proteomics. (in press)Impact Factor: 9.4 (PDF)


Siu Kwan Sze*, Wei Wang, Wei Meng, Randong Yuan, Tiannan Guo, Yi Zhu, James P.Tam*.

Elucidating structure of cyclotide by partial acid hydrolysis and LC-MS/MS analysis.

Analytical Chemistry. 2009, 81, (3), 1079-88. Impact Factor: 5.3 (PDF)


Wei Meng, Huoming Zhang, Tiannan Guo, Chhiti Pandey, Yi Zhu, Oi Lian Kon, Siu Kwan Sze.

A one-step precedure for peptide extraction from in-gel digestion sample for mass spectrometric analysis.

Analytical Chemistry, 2008. 80 (24): 9797–9805. Impact Factor: 5.3 (PDF)


Guo Tiannan, Gan Chee Sian, Zhang Huoming, Zhu Yi, Kon Oi Lian, Sze Siu Kwan,

Hybridization of Pulsed-Q Dissociation and Collision-Activated Dissociation in Linear Ion Trap Mass Spectrometer for iTRAQ Quantitation,

Journal of Proteome Research,2008, 7(11), pp 4831-4840. Impact Factor: 5.7 (PDF)


Gan Chee Sian, Guo Tiannan, Zhang Huoming, Lim Sai Kiang and Sze Siu Kwan,

A Comparative Study of Electrostatic Repulsion-Hydrophilic Interaction Chromatography (ERLIC) versus SCX-IMAC-Based Methods for Phosphopeptide Isolation/Enrichment,

Journal of Proteome Research, 2008. 7(11), pp 4869-4877. Impact Factor: 5.7 (PDF)


Sze SK, de Kleijn DP, Lai, RC, Tan EKY, Zhao, H, Yeo KS, Low TY, Lian Q, Lee, CN, Mitchell, W, El Oakley RM, and Lim S-K.

Elucidating the secretion proteome of human ESC-derived mesenchymal stem cells.

Molecular and Cellular Proteomics, 6(10), 1680-9, 2007. Impact Factor: 9.4


Timmers L, Sluijter JP, Verlaan CW, Steendijk P, Cramer MJ, Emons M, Strijder C, Grundeman PF, Sze SK, Hua L, Piek JJ, Borst C, Pasterkamp G, de Kleijn DP,

Cyclooxygenase-2 Inhibition Increases Mortality, Enhances Left Ventricular Remodeling, and Impairs Systolic Function After Myocardial Infarction in the Pig,

Circulation. 115(3), 326-32, 2007. Impact Factor: 12.8


This paper is cited in the guidelines for the management of patients with a heart attack. This shows that our work is relevant for the patient. We are truly working from the bench towards the bed.

2007 Focused Update of the ACC/AHA 2004 Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction J. Am. Coll. Cardiol. 2008;51;210-247.

Citation: Because of the known increased risk of cardiovascular events among patients taking cyclooxygenase-2 (COX-2) inhibitors and other nonsteroidal anti-inflammatory drugs (NSAIDs) (17–19), these drugs should be discontinued immediately at the time of STEMI (see 2004 STEMI Guidelines, Section 7.12.5, for additional discussion) (3,15,20,21).

Ref 21.

Timmers L, Sluijter JP, Verlaan CW, Steendijk P, Cramer MJ, Emons M, Strijder C, Gründeman PF, Sze SK, Hua L, Piek JJ, Borst C, Pasterkamp G, de Kleijn DP. Cyclooxygenase-2 inhibition increases mortality, enhances left ventricular remodeling, and impairs systolic function after myocardial infarction in the pig. Circulation 2007;115:326 –32.


ChenY, Low TY, Lin Q, Choong LY, Tan YL, Sze SK, Druker BJ and Lim YP,

Phosphoproteomics snapshot of EGF signaling in A431 human cancer cells reveals a major contribution from proteins implicated in cell adhesion and chemotaxis,

Proteomics, 7, 2384-97, 2007. Impact Factor: 5.5


Chen L, Sze SK* and Yang H*,

Automated Intensity Descent Method (AID-HRMS) for Efficient Interpretation of Complex High Resolution Mass Spectra of Proteins,

Analytical Chemistry, 78(14),5006-18,2006. (*corresponding authors) Impact Factor: 5.3


Wong JJY, Pung YF, Sze NSK and Chin KC,

HERC5 is a novel interferon-induced HECT-type E3 protein ligase that mediates Type I interferon-induced ISGylation of protein targets,

Proceedings of the National Academy of Sciences of the USA, 103(28),10735-40, 2006. Impact Factor: 9.6


Wu Q, Chen X, Zhang J, Loh YH, Low TY, Zhang WW, Zhang WS, Sze SK, Lim B, and Ng H.H.,

Sall4 is a Nanog interacting protein, which co-occupies Nanog genomic sites in embryonic stem cells,

Journal of Biological Chemistry, 281(34), 24090-4, 2006. Impact Factor: 5.6


Guo X, Chan-Park M*, Yoon SF, Chun J, Hua L, and Sze NSK*,

UV Embossed Polymeric Chip for Protein Separation and Identification based on Capillary Isoelectric Focusing and MALDI-TOF-MS,

Analytical Chemistry, 78, 3249-3256, 2006. (*corresponding authors) Impact Factor: 5.3


Hua L, Low TY, and Sze SK,

Microwave-assisted Specific Chemical Digestion for Rapid Protein Identification,

Proteomics, 6, 586-591, 2006. Impact Factor: 5.5

  before 2006  

Aye TT, Low TY, and Sze SK,

Nanosecond Laser Induced Photochemical Oxidation method for Protein Surface Mapping with Mass Spectrometry,

Analytical Chemistry, 77(18), 5814-5822, 2005. Impact Factor: 5.3


Sze SK, Ge Y, Oh H, and McLafferty FW,

Plasma Electron Capture Dissociation for Large Protein,

Analytical Chemistry, 75, 1599-1603, 2003. Impact Factor: 5.3


Sze SK, Ge Y, Oh H, and McLafferty FW,

Top Down Mass Spectrometry of a 29 kDa Protein for Characterization of Any Posttranslational Modification to Within One Residue,

Proceedings of the National Academy of Sciences of the USA. 99, 1774-1779, 2002. Impact Factor: 9.6

  updated Aug 2010.  
  Return to Newman Sze's proteomics lab